Can I take a bus to Talca when I arrive in Chile?

Hello
I believe that you cannot travel on public transport to a place as far away as Talca. This rule applied to all of my Chilean clients. The rule is you that you need to reach your place of quarantine within 2 hours and you cannot take public transport.
The good news is that, unless you come from a country like South Africa, if you have your Chilean pasaporte sanitario, your time in quarantine will only be around 12 hours. You will be subject to a PCR test when you arrive at the airport and the results come really fast. Mine was in 8 hours. Once you have the negative result you can go wherever you want.

There are plenty of places on-line to buy a bus ticket Santiago - Talca, the trip taking 3-4 hours.  There is no mention of a time limit, so you may want to try to talk to someone using the contact info found on the web page.

The first link below has as an option, renting a car yourself, or hiring a driver, Santiago - Talca.  You may be able to avoid the quarantine restrictions doing that, versus taking a bus, and it's not that expensive:

https://www.rome2rio.com/map/Santiago/Talcahttps://www.chilepasajes.cl/es/pasajes/ … iago/talcahttps://www.busbud.com/en/bus-santiago- … cf4-63tn3xhttps://www.recorrido.cl/en/bus/santiago/talca