I am not aware of any threshold at which moskitos can not fly within PR, as they tend not to file a flight plan.
The main control is removing stagnant water. A lot of people have cans, tires, etc in their yard that collect water and allow mosquitos to thrive.
No blood to suck also limits them, so less populated areas will have less mosquitos.
Spraying affect other bugs and animals like the coqui, if one can not remove a water collecting container, a thin film of oil will cause them to die also small fish like the guppies help control the population.