Where do you plan to start you tour? I know the area above Adjuntas/Ponce, Juana Dias Coamo, Torro Negro towards Aibonito and Cayey. This can be done in an afternoon with a full tank of gas. This route has various stopping points including Torro Negro. Highway 10 is a good way to exit or enter Ruta Panoramica. It is a midway point of the Island. Highway #2 Ponce to Ruta 143 is about a half hour or less. Highway #2 Arecibo to Ruta 143 is about an hour or a bit more depending on truck traffic. The other ways like coamo, Yauco, San Sebastion can be windy not to be done at night or with rain or fog. The other section is from Mayaguez, Las Marias. Sans Sebastion towards Yauco, Laras, Adjuntas. Driving the curves can get tiresome in places but the Adjuntas-Cayey is more manageable that the Adjuntas to Yauco. There are magnficent views from many places. Vendors are usually open Thurs, Fri, Sat Sun. Sometimes jeep and motorcycle rallies take place during the weekend and you can get caught in traffic Jams. Thurs. Or Fri are my preferred times to travel. Torro Negro has some beautiful swimming spots. They are just below the camping area with soft waterfalls. there are 3 or four pools each very relaxing cool and clear. Very few people go to them so you will have them to yourself unless campers are there.