Traveling outside of the US after a B1 B2 visa approval

Does anyone know if it is okay to travel back to your home country after your B1 B2 visa has been approved? I know it´s a multi entry visa but I just wanted to make sure. My first application was approved, I  then had to put on an application for an extension that also got approved and am now on my third application waiting for it to be approved and will need to file for another extension right after that. I am just wondering if I could travel back home for a couple of weeks and then come straight back to put in the application? Any advice greatly appreciated.

Thank you